Research area: Toxicogenomics and Toxicology
Carlha Gutiérrez Lovera has a BSc degree in Biology at the University of Carabobo (Venezuela). During this period, she was selected to work in a national research project on which she carried out an evaluation of parasitic diseases in cocoa trees by the association between inoculation injuries and molecular markers. Also she was teacher’s assistant at the Microbiology laboratory at the same University and she did two interships: i) at the National Institute of Agriculture Research (Phytopathology laboratory), and ii) at the University of Los Andes (Laboratory of Genetics and Cellular Chemistry). Later, she obtained a MSc degree at the University Santiago de Compostela (Spain) and a Professor Master's degree at the Camilo José Cela University. Thereafter, she optimized some techniques of solid-phase extraction with nanomaterials to determine several chemical compounds by capillary electrophoresis and electrothermal atomic absorption spectrometry. Currenly, her PhD thesis focuses on studying the toxicity, biodistribution and therapeutic efficacy of antitumoral nanosystems in zebrafish embryos and human cancer cell. This involves analysis of acute and chronic toxicity, inmunotoxicity, biodistribution in real-time by confocal microscopy, interaction macrophage-nanosystem, xenograft tumor cells and toxicogenomics studies by qPCR, microarrays and RNA sequencing (RNA-seq).