Zebrafish Research

  • Developmentally-programmed celular senescence is conserved and widespread in zebrafish.

    Da Silva-Álvarez S., Guerra-Varela J., Sobrido-Cameán D., Quelle A., Barreiro-Iglesias A., Sánchez L. & Collado M.

    Biology Open (submitted) 2019


    Quantification of morphological abnormalities and metabolism related changes in xenografted zebrafish embryos at different incubation temperatures.

    Cabezas-Sáinz P., Coppel C., Dorrego P., Muinelo L., Rubiolo J.A. & Sánchez L.

    Zebrafish (submitted) 2019


    Cell senescence contributes to tissue regeneration in zebrafish: Tissue injury-induced celular senescence contributes to regeneration in zebrafish.

    Da Silva-Álvarez S., Guerra-Varela J., Barreiro-Iglesias A., Sánchez L. & Collado M.

    Aging Cell (under revision) 2019


    The size and composition of polymeric nanocapsules dictate their interaction with macrophages and biodistribution in zebrafish.

    Crecente-Campo J., Guerra-Varela J., Peleteiro M., Gutiérrez-Lovera C., Fernández-Mariño I., Diéguez-Docampo A., González-Fernández A., Sánchez L. & Alonso M.J.

    Journal of Controlled Release (under revision) 2019


    Breast tumor cell recruit tumor-associated macrophages through Pit-1 and CXCL12 favoring metástasis in lung.

    Seoane S., Martínez-Ordóñez A., Eiro N., Cabezas-Sáinz P., González L.O., Sánchez L., Vizoso F. & Pérez-Fernández R.

    Journal of Pathology (under revision) 2019


    In vivo toxicity assays in zebrafish embryos as a pre-requisit in a xenograft preclinical studies

    Gutiérrez-Lovera C., Martínez-Val J., Cabezas-Sáinz P., López R., Rubiolo J.A. & Sánchez L.

    Toxicology Mechanisms & Methods (doi: 10.1080/15376516.2019.16119802019


    Serotonin inhibits axonal regeneration of identificable descending neurons after a complete spinal cord injury in lampreys

    Sobrido-Cameán D., Robledo D., Sánchez L., Rodicio M.C. & Barreiro-Iglesias A.

    Diseases Models and Mechanism, 12: dmm037085. (doi: 10.1242/dmm.0370852019


    CTCs-derived xenograft development in a Triple Negative breast cancer case

    Pereira-Veiga T., Abreu M., Robledo D., Matias-Guiu X., Santacana M., Sánchez L., Cueva J., Palacios P., Abdulkader I., López-López R., Muinelo-Romay L. & Costa C.

    Journal of International Cancer 144: 2254-2265. (doi: 10.1002/ijc.32001)2019


    Glycosylated cell penetrating peptides GCPPs.

    Gallego I., Rioboo A., Reina J.J., Díaz B., Canales-Mayordomo A., Cañada J., Guerra-Varela J., Sánchez L. & Montenegro J.

    ChemBiochem, 20: 1400-1409 ( 2019


    Gomesin inhibits melanoma growth by manipulating key signaling cascades that control cell death and proliferation

    Ikonomopoulou M.P., Pineda S.S., Fernández-Rojo M.A., Cabezas-Sáinz P., Winnen B., Morales R.A.V., Brust A., Sánchez L.E., Alewood P., Ramm G.A., Miles J.J. & King G.F.

    Scientific Reports  8: 11519. (doi: 10.1038/s41598-018-29826-42018


    First description of a natural infection with spleen and kidney necrosis virus in zebrafish

    Bermúdez R., Losada A.P., de Azevedo A.M., Guerra-Varela J., Pérez-Fernández D., Sánchez L., Padrós F., Nowak B. & Quiroga M.I.

    Journal of Fish Diseases, 41: 1283-1294 (doi: 10.1111/jfd.12822) 2018


    Breast cancer metastasis to liver and lung is facilitated by Pit-1-CXCL12-CXCR4 axis

    Martínez Ordóñez-A., Seoane S., Cabezas-Sáinz P., Eiro N., Sendón-Lago J., Macía M., García Caballero T., González L.O., Sánchez L., Vizoso F. & Pérez-Fernández R.

    Oncogene, 37: 1430-1444 (doi: 10.1038/s41388-017-0036-8). 2018


    Susceptibility of zebrafish  to Vesicular Stomatitis Virus infection

    Guerra-Varela J., Baz-Martínez M., Da Silva-Álvarez S., Losada A.P., Quiroga M.I., Collado M., Rivas C. & Sánchez L.

    Zebrafish, 15: 124-132 (doi: 10.1089/zeb.2017.1499). 2018


    Improving zebrafish embryo xenotransplantation conditions by increasing incubation temperature and establishing proliferation index with ZFtool.

    Cabezas-Sáinz P., Guerra-Varela J., Carreira M.J., Mariscal J., Roel M., Rubiolo J.A., Sciara A.A., Abal M., Botana L.M., López R. & Sánchez L.

    BMC Cancer, 18:3 (10.1186/s12885-017-3919-8). 2018


    Assessment of the permeability and toxicity of polymeric nanocapsules using the zebrafish model

    Teijeiro-Valiño C., Yebra-Pimentel E., Guerra-Varela J., Csaba N., Alonso M.A. & Sánchez L.

    Nanomedicine, 12: 2069-2082  (doi: 10.2217/nnm-2017-0078). 2017


    Dinuclear RuII(bipy)2 derivatives: structural, biological, and in vivo zebrafish toxicity evaluation.

    Lenis-Rojas OA., Roma-Rodrigues C., Fernandes AR., Marques F., Pérez-Fernández D., Guerra-Varela J., Sánchez L., Vázquez-García D., López-Torres M., Fernández A. & Fernández JJ.

    Inorganic Chemistry, 56: 7127-7144 (doi:10.1021/acs.inorgchem.7b00790). 2017


    The potential of zebrafish for improving the translation of genetic anticancer nanomedicines

    Gutiérrez-Lovera C., Vázquez-Ríos A., Guerra-Varela J., Sánchez L. & de la Fuente M.

    Genes 8: 349 (doi:10.3390/genes8120349). 2017


    Heteroleptic mononuclear compounds of ruthenium (II): synthesis, structural analyses, in vitro antitumor activity and in vivo toxicity on zebrafish embryos.

    Lenis-Rojas O.A., Fernandes A.R., Roma-Rodrigues C., Baptista P.V., Marques F., Pérez-Fernández D., Guerra-Varela J., Sánchez L., Vázquez-García D., López Torres M., Fernández A. & Fernández J.J.

    Dalton Transactions, 45: 19127-19140 (doi: 10.1039/C6DT03591D). 2016


    Cell senescence is an antiviral defense mechanism.

    Baz-Martínez M., Da Silva-Álvarez S., Rodríguez E., Guerra J., El Motiam A., Vidal A., García-Caballero T., González-Barcia M., Sánchez L., Muñoz-Fontela C., Collado M. & Rivas C.

    Scientific Reports, 6: 37007. (doi:10.1038/srep37007). 2016


    Marine guanidine alkaloids crambescidins inhibit tumor growth and activate intrinsic apoptotic signaling inducing tumor regression in a colorectal carcinoma zebrafish xenograft model.

    Roel M., Rubiolo J.A., Guerra-Varela J., Silva Siguara B. L., Thomas O.P., Cabezas-Sainz P., López R., Sánchez L. & Botana L.M.

    Oncotarget, 7: 83071-83087. (doi: 10.18632/oncotarget.13068). 2016


    “A zebra in the water”: Inspiring science in Spain.

    Guerra-Varela J., Cabezas-Sáinz P., Yebra-Pimentel E., Gutiérrez-Lovera C., Cedrón V.P., Otero Obarrio M.A., Sciara A.A., Rodríguez N., Araujo J., Millán A. & Sánchez L.

    Zebrafish, 13(4): 241-247. (doi:10.1089/zeb.2015.1178). 2016


    Light-controlled celular internalization and cytotoxicity of nucleic acid-binding agents. Studies in vitro and in zebrafish embryos.

    Penas C., Sánchez M.I., Guerra-Varela J., Sánchez L., Vázquez M.E. & Mascareñas J.L.

    ChemBioChem, 17: 37-41. (doi: 10.1002/cbic.201500455). 2016

Aquatic Genomics

  • Whole genome sequencing of turbot (Scophthalmus maximus; Pleuronectiformes): a fish adapted to demersal life.

    Figueras A., Robledo D., Corvelo A., Hermida M., Pereiro P., Rubiolo J. A., Gómez-Garrido J., Carreté L., Bello X., Gut M., Gut I.G., Marcet-Houben M., Forn-Cuní G., Galán B., García J.L., Abal-Fabeiro J.L., Pardo B.G., Taboada X., Fernández C., Vlasova A., Hermoso-Pulido A., Guigo R., Alvarez-Dios J. A., Gómez-Tato A., Viñas A., Maside X., Gabaldón T., Novoa B., Bouza C., Alioto T. & Martínez P.

    DNA Research, 23: 181-192 (doi: 10.1093/dnares/dsw007). 2016.


    Gene expression analysis at the onset of sex differentiation in turbot (Scophthalmus maximus).

    Robledo D., Ribas L., Cal R., Sánchez L., Piferrer F., Martínez P. & Viñas A.

    BMC Genomics, 16: 973 (doi: 10.1186/s12864-015-2142-8). 2015.


    Screening of repetitive motifs inside the genome of the flat oyster (Ostrea edulis): Transposable elements and short tandem repeats.

    Vera M., Bello X., Álvarez-Dios J.A., Pardo B.G., Sánchez L., Carlsson J., Carlsson J.E.L., Carolina Bartolomé C., Maside X. & Martinez P.

    Marine Genomics, 24: 335-341 (doi:10.1016/j.margen.2015.08.006). 2015.


    Genetic architecture of sex determination in fish: Applications to sex ratio control in aquaculture.

    Martínez P., Viñas A.M., Sánchez L., Díaz N., Ribas L. & Piferrer.

    Frontiers in Genetics, 5: 340 (doi: 10.3389/fgene.2014.00340). 2014.


    Analysis of qPCR reference gene stability determination methods and a practical approach for efficiency calculation on a turbot (Scophthalmus maximus) gonad dataset.

    Robledo D., Hernández-Urcera J., Cal R.M., Pardo B.G., Sánchez L., Martínez P. & Viñas A. 

    BMC Genomics, 15: 648 (doi: 10.1186/1471-2164-15-648). 2014.


    A sex-associated sequence identified by RAPD screening in gynogenetic individuals of turbot (Scophthalmus maximus).

    Vale L., Diéguez R., Sánchez L., Martínez, P. & Viñas A. 2014

    Molecular Biology Reports, 41: 1501-1509 (doi: 10.1007/s11033-013-2995-3). 2014.

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